Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation

Small particles are of great interest in a variety applications. Spray drying is common technique for particle synthesis, but it limited with respect to sizes below 10 μm. Therefore, new laboratory-scale spray dryer was designed address this issue. A novel aerosol generator consisting piezo crystal swirl chamber obtain droplets the low micrometer range. After and cooling, were deposited molten carrier, using melt electrostatic precipitation. The median size three pharmaceutical drug substances 2 distribution particularly narrow, span values about 1.1. sufficient produce small 5 μm ultrasonic atomization at high frequencies. Electrostatic precipitation carrier suitable method capture these particles.